ATP modulates SLC7A5 (LAT1) synergistically with cholesterol
نویسندگان
چکیده
منابع مشابه
Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol
LAT1 (SLC7A5) is a transporter for both the uptake of large neutral amino acids and a number of pharmaceutical drugs. It is expressed in numerous cell types including T-cells, cancer cells and brain endothelial cells. However, mechanistic knowledge of how it functions and its interactions with lipids are unknown or limited due to inability of obtaining stable purified protein in sufficient quan...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-73757-y